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Systematic Exploration of Indolizine-Based Small Fluorescent Molecules

Synthesis, Analysis and Application

Cover Systematic Exploration of Indolizine-Based Small Fluorescent Molecules
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This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.
Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. ...
Beschreibung
This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.


Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under live cell conditions.


Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.

Cover Systematic Exploration of Indolizine-Based Small Fluorescent Molecules
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Veröffentlicht 2018, von Youngjun Lee bei Springer Singapore

ISBN: 978-981-131-644-9
Auflage: 1st ed. 2018
Reihe: Springer Theses
XXV, 187 Seiten
23.5 cm x 15.5 cm

Über Youngjun Lee


<p>Dr. Youngjun Lee is a member of CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Korea. He earned Ph.D. degree in organic chemistry at SNU in February 2018.</p>


Über Youngjun Lee

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